HarkerBIO activities focus on the determination and use of macromolecular structures to solve research challenges in Pharma and Biotech; the services include a full suite of gene-to-structure activities, advanced molecular biology, protein chemistry, protein design and protein optimization. Some of HarkerBIO's more specialized offerings include crystallization of full-length antibodies and a proprietary technology (dubbed 'Adaptive Surface Alphabet') that can convert poorly crystalline (or entirely non - crystallizeable ) proteins into those suitable for iterative ligand soaking, fragment screening etc. HarkerBIO utilizes the highly successful custom robotic screening pipeline at HWI as well as ARI robotics for follow-up and custom screen creation. We use the Crystal Gryphon for setting up assay plates, the Scorpion for designing optimization screens and re-arraying commercial screens into deep well blocks. Both of these instruments have been workhorses for our lab.